![]() Ecto Cooler had a brief return for the 2016 ‘Ghostbusters’ reboot, but due to new advertising restrictions, could not feature Slimer in its updated Hi-C packaging. To celebrate the release of last year’s release of Ghostbusters: Afterlife, Coca-Cola brought back fan-favorite Hi-C Ecto Cooler, albeit, as part of a highly commemorative release, with bottles only being handed out at the New York City premiere or awarded to lucky fans through social media. To celebrate the release of Ghostbusters: Afterlife, the Coca-Cola Company and Sony Pictures are now bringing back Hi-C ‘s Ecto Cooler. The beverage was then renamed ‘Shoutin’ Orange Tangergreen,’ then ‘Crazy Citrus Cooler,’ before being pulled from store shelves entirely in 2007. Ecto Cooler retained its popularity for years, surviving even ‘The Real Ghostbusters’ before the ‘Ghostbusters’ branding was removed from the drink. The ‘Ghostbusters’ tie-in began in 1987 in promotion of ‘The Real Ghostbusters’ animated series, debuting as rebranded version of Hi-C’s Citrus Cooler drink. This latest Ecto Cooler news adds to the storied history of the famous slime-green drink. Word is that Ecto Cooler will be exclusively rolled out at promotional events for ‘Ghostbusters: Afterlife,’ with no wide production planned by Hi-C as of yet.įansite Ghostbusters News reported that supplies of Hi-C’s Ecto Cooler will be “HIGHLY limited,” only making an appearance strictly as a promotional item at ‘Ghostbusters: Afterlife’-themed events. ![]() The familiar face of Slimer and the green boxed drink won’t be hitting your grocery store’s shelves this fall, unfortunately. Then Adam Savage has announced a behind the scenes series for Afterlife where he learns all the secrets in front and behind the camera on the new film, Troys. In honor of the new movie, Hi-C is reviving one its most successful tie-in products of all time. We don’t mind it, especially this latest bit of news: Hi-C’s famed Ecto Cooler will make its return! There’s some fine print, though. Ghostbusters: Afterlife hits theaters on November 19, 2021. Between the Reitman family featurette and the return of Dan Aykroyd to the franchise, the ‘Ghostbusters: Afterlife’ promotional rollout is leaning heavily into nostalgia.
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Despite its obvious importance, structural and mechanistic insight on how alternative mRNA processing decisions are executed remains sparse. More puzzling are situations where poly(A) site selection is controlled instead by altering the intracellular levels of general processing factors such as CstF-64 ( Takagaki et al., 1996 Colgan and Manley, 1997 Takagaki and Manley, 1998). ![]() ![]() In some cases, of which U1A is the best understood example ( Boelens et al., 1993), the timing and efficiency of polyadenylation decisions are controlled by gene-specific factors and their interaction with specific RNA elements and with the polyadenylation machinery. In polyadenylation, as in splicing, the efficiency with which different processing sites are utilized is controlled by regulatory cis-acting RNA elements and their interactions with trans-acting protein factors. Differential usage of alternative poly(A) sites produces mature transcripts with distinctive 3′-UTRs and gene expression profiles and, sometimes, even different coding sequences. Furthermore, an increasing number of developmental and differentiation decisions are now known to be executed by alternative polyadenylation of the same mRNA ( Barabino and Keller, 1999 Zhao et al., 1999). However, ∼30% of all human mRNAs contain alternative polyadenylation signals ( Beaudoing et al., 2000). Alternative splicing has long been recognized as a major source of diversity in gene expression, while polyadenylation has been considered largely constitutive. Maturation of mRNA precursors is a constitutive process for most transcripts but is also a major regulatory event in eukaryotic cells, producing multiple isoforms of the same mRNA by alternative processing. The structural distinction between sequences that form stable and unstable complexes provides an operational distinction between weakly and strongly processed poly(A) sites. The protein–RNA interface remains mobile, most likely a requirement to bind many GU-rich sequences and yet discriminate against other RNAs. Contacts outside the UU pocket fine tune the protein–RNA interaction and provide different affinities for distinct GU-rich elements. Consecutive Us are required for a strong CstF–GU interaction and we show how UU dinucleotides are recognized. We propose that this conformational change initiates assembly. The C-terminal helix unfolds upon RNA binding and extends into the hinge domain where interactions with factors responsible for assembly of the polyadenylation complex occur. We present the structure of the RNA-binding domain of CstF-64 containing an RNA recognition motif (RRM) augmented by N- and C-terminal helices. These are recognized by a heterotrimeric protein complex (CstF) through its 64 kDa subunit (CstF-64) the strength of this interaction affects the efficiency of poly(A) site utilization. Vertebrate polyadenylation sites are identified by the AAUAAA signal and by GU-rich sequences downstream of the cleavage site. ![]() The higher the ratio, the greater the associated growth and resilience. Positive psychology tells us that the “optimal” ratio is 3 to 1 and this is the ratio above which the people are found to be “flourishing” (you can read more about the ratio and how to calculate it here). The key is not to eliminate negativity or distract ourselves from it, but to keep our ratio of positive to negative emotions within healthy limits.
The sound effects of guns being fired, the oomph you feel when they’re fired, all contribute to a more satisfying gunplay experience. But I do prefer Modern Warfare overall for a variety of reasons. There will be those who prefer Cold War over Modern Warfare and vice versa, and far be it from me to say one is objectively better than the other. They are simply nothing alike, for better or worse. Where the two games- Modern Warfare and Cold War-wildly diverge is in multiplayer. It even includes at least one crossover character from the Modern Warfare universe, as these two franchises grow ever closer. Is the campaign as good as Modern Warfare 2019’s? I think so, actually. I enjoy getting through a campaign in just a few sittings. Par for the course when it comes to this franchise, which is fine by me. Maybe 7 or 8 hours depending on your skill level, how much time you spend searching for evidence and exploring and the difficulty setting you select. Hopefully we see much more of this in future Call Of Duty games. These aren’t simply puzzles like you might find in an Uncharted game, either. Suffice to say, I absolutely loved solving these and their addition to the campaign makes it that much better. ![]() To get a sense of these puzzles, check out my guides here and here. These puzzles are actually quite good, and can’t simply be looked up online to solve. The campaign isn’t long, but you’ll likely have to play some missions more than once to gather evidence which is used in a pair of puzzles that are required to complete in order to complete the side missions the correct way. Familiar faces like Frank Woods and Alex Mason return to the fold, and you’ll play some missions as Mason though these are side-missions. The campaign’s story focuses largely on your boss, Russell Adler, and his pursuit of Soviet spy Perseus. ![]() The final act is Black Ops at its weirdest and most inventive. And it turns out you’re quite the enigma. You play as a couple different characters depending on the mission, but primarily you’re a character whose gender, backstory and so forth you create yourself. It’s a solid, exciting campaign with some interesting twists and turns, a trippy ending(s) and some cool puzzles to solve. I really enjoyed the Call Of Duty: Black Ops Cold War campaign. Call Of Duty: Black Ops Cold War Credit: Treyarch ![]() Tap “Disable and Delete” and you’ll disable iCloud Photo Library and delete the photos from Apple’s servers. If you’ve uploaded all your photos to Google Photos or another service, you can tap “iCloud Photo Library” under Photos here to disable iCloud Photo Library. Here are a few common things we recommend looking at.ĭisable and Delete Your iCloud Photo Library To view more details, tap “Storage” on the iCloud screen and tap “Manage Storage.” You’ll see the amount of space you have available and a breakdown of what’s taking up space in iCloud here, which will help you decide what you need to delete. ![]() To access your iCloud settings, open the Settings app and tap “iCloud.” Scroll down to “Backup” and check that iCloud Backup is “On” to confirm you’re using it on your current device. Allow the app to upload your photos with “High quality (free unlimited storage).” The Assistant screen in the app will show you the progress and you can view your photos on the web. To back up your photos with Google Photos, install the Google Photos app and enable the “Back up & sync” option. RELATED: Banish iCloud Storage Nagging with Google Photos You can also access Google Photos on the web, and there’s an Android app–something which makes it more cross-platform than Apple’s solution. There are other photo storage apps you could potentially use, like Flickr, but we really do recommend Google Photos. ![]() Google Photos offers completely free storage of an unlimited number of photos as long as you’re willing to automatically compress them a bit to “high quality.” It even supports live photos now. Instead, just dump iCloud Photo Library and use an alternative service. But it's important to create a public record of bugs that exist and have yet to be addressed.You don’t have to give up those convenient online photo backups. FWIW i knew i wasn't going to get any answers or help here, i searched the issue beforehand and others have this problem too. ![]() It's just disappointing how much apple has gone downhill since i first got an iphone. And finally, yes, as i described in the previous post, i've manually deleted and then created new backups multiple times over the last two years.And there are times when my phone is plugged in, on wifi, and locked in the middle of the day, but no backups happen then either. As for the internet connection, we are forced to use c*mcast, and while our service is garbage, it's not cutting out every single night.What is happening is that i enter new contacts consisting of names and mobile numbers directly into my phone's contact list, but they disappear. I've never allowed any apps to import or access contacts. for contacts, i have the gmail app which i use in addition to the native ios mail (linked to my icloud email, of course).Thanks for taking time to respond, I'm sorry to report that none of these scenarios account for what's taking place. Icloud got stuck in the past at some point and i can no longer trust it to work for any really important stuff. Lol this is why i had to write all my contacts down on paper, icloud kept deleting them as if it were doing backups in reverse, it kept deleting the new stuff and returning my contact list to a previous state. But the fact that ancient data from two years ago is still randomly showing up *despite having been "deleted"* tells me that something beyond my control is malfunctioning with icloud. I've gone through this whole 'backup reset' process of deleting previous backups and resetting at least 3 times now. 22, despite having the setting for backups turned on. But no backup has taken place since I posted the question, in just the same way that no backups have taken place since Feb. "iCloud backups should happen automatically once a day if certain conditions are met:" I've double checked, and all these conditions should be met when I plug my phone in at night. ![]() The therapeutic effects of qigong in patients with chronic obstructive pulmonary disease in the stable stage: a meta-analysis. Efficacy and tolerability of a polysaccharide-resin-honey based cough syrup as compared to carbocysteine syrup for children with colds: a randomized, single-blinded, multicenter study. doi:10.1002/3Ĭohen HA, Hoshen M, Gur S, Bahir A, Laks Y, Blau H. Chest physiotherapy compared to no chest physiotherapy for cystic fibrosis. Mucolytics for COPD: negotiating a slippery slope towards proof of efficacy. Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease. Qigong, a practice of breathing exercises and movements, may also help.A few herbs-including mao huang ( Herba ephedrae), tao ren ( Semen persicae), and Huang qin ( Radix scutellariae)-may ease the symptoms of respiratory disease.While there are anecdotal reports that they are helpful, the scientific data is not clear about the benefits. ![]()
“If women are saddled with a burden of caretaking for either children or elder members of their families, they’re not able to engage the workplace. “Family leave is a critical part of reaching pay equity,” Twillie says. Furthermore, Twillie says many organizations still have inadequate family leave. That said, the impending recession has sparked layoffs and hiring freezes and at many companies putting all job seekers – especially Black women – at a disadvantage. “I am starting to see a lot of companies create better wellness packages, whether it’s paying for Headspace for employees or giving them a stipend, so they can actually seek a therapist or do something that improves their mental health,” she says. Thankfully, Lopez says many companies are working to make their organizations a place where workers want to stay. More than anything else, the women surveyed cited feelings of burnout as their main reason for leaving. “COVID empowered workers and caused them to question if their work situation was really working for them,” Lopez says.Ī 2021 survey by career company Fairygodboss and nFormation, a community for and by professional women of color, found that approximately one-third of all women of color were planning to leave their jobs by 2022. Armed with new data, many Black women chose to seek out better jobs. “A lot of the awareness and conversations around pay equity and total compensation packages are really moving the needle,” says Ariel Lopez, career coach and founder and CEO at Knac, a data-driven talent evaluation platform that helps companies diversify their candidate pools.Īdditionally, Lopez says that apps like Blind and Fishbowl, which allow employees to have anonymous candid conversations, can shed light on issues such as compensation and workplace culture. Moving the Needleįrom COVID’s disproportionate impact on people of color to the social unrest sparked by racially motivated police violence, 2020 made more people aware of institutional racism and sexism and ignited much-needed dialog and steps toward change. These wage discrepancies can result in Black women losing close to $1 million over the course of a 40-year career. The wage gap seems to start with girls as young as 16 and continues to worsen as Black women progress through their education and careers, according to a study from ESSENCE and that was presented at a recent symposium called “Black Women Deserve Fair Pay.” (You can listen in on the full conversation here.) Even though Black women enroll in college at higher rates than men, Black women who have bachelor’s degrees still earn 36% less than white men with bachelor’s degrees on average. “It’s going to take quite a long time for Black women to recover,” says Jacqueline Twillie, founder and CEO at, a professional development company focused on closing gender wage and leadership gaps.īlack women earn 42% less than their non-BIPOC male counterparts and 20% less than non-BIPOC women. ![]() Based on ACS Census data, the 2021 wage gap for Black women compared to non-Hispanic white men was 58 cents. For full-time Black women workers, the median wage went down compared to the year before. In 2020, Black women made 63% of what White, non-Hispanic men made - a ratio that closely resembles the gender wage gap of the 1960s. Over half of Black women surveyed in a 2020 study by ESSENCE reported that they were facing or anticipating a negative financial impact as a result of the pandemic. ![]() In other words, the wage gap for Black women is widening. ![]() In 2021, Black Women’s Equal Pay Day was recognized on August 3, but this year it’s been pushed back by nearly two months. It’s always a date we’d rather not be marking, but in 2022, it’s time to stop and take a long look at the wage inequities that Black women face. Septemis Black Women’s Equal Pay Day, which marks how far into the year Black women must work - for free- just to earn what men earned the previous year. ![]() Not everybody at the marina is as equally thrilled about their teeth rattling as you may be. less loud thanks to the "captain's call" exhaust system allowing you to change from through the transom thunder to underwater rumble with the flip of a switch. Propelled by a supercharged fresh water cooled Mercruiser 496 with well over 600hp and tough Bravo One X drive with external hydraulic steering and high performance trim tabs this boat is all about speed, as measured by the Tattle-Tale GPS speedometer, and good looks, period.īut fast and loud is not the only choice, you've also got fast and. If you have a need for speed, this is the vessel indeed. In the world of racing pedigree boats you've got Fountain, Cigarette, Eliminator, Baja and more, among them stretching back to the early 60's is Checkmate, founded for racing and have always been about racing. See all 104 photos at www popyachts com/view/244849ġ987 High Performance Checkmate Convincor with 496 whipple super charger. Only 80 photos available on this website. If you're in the Philadelphia, Reading, Upper Darby, or Trenton areas, please use the form on this page to let me know what you're looking for and I'll get back with you today about any other high performance boat options we have locally that may meet your needs. We have several more Sea Ray, Scarab, and Fountain vessels for sale. ![]() This boat will be a great boat for the bay. This boat can get you, and three others where you want to be, enjoy the tunes on your pioneer stereo and enjoy the comfort of the pads that will keep you snug when you are motoring to your next destination. This boat has been well taken care of being cleaned and stored in covered storage after every use. The 1995 Checkmate Convincer cruises in the 50s MPH and can get up to over 70mph. On the dyno, Extension box with a bravo One drive!Īre you looking for a boat that will get you noticed with style and speed? Reason for selling is "Moving to Florida".Ģ8' Convincer with a 548 big block, 725 HP. See all 136 photos at www popyachts com/view/255111 Call us at (941) 914-9217 to discuss this vessel today. If you're in the Columbus, Newark, Mansfield, or Violet areas, please use the form on this page to let me know what you're looking for and I'll get back with you today about any other high performance boat options we have locally that may meet your needs. We have several more Sea Ray, Baja, and Formula vessels for sale. While we will always attempt to provide you with a TRUE representation of every vessel we market, during any purchase from Pop you will be encouraged to schedule an inspection from an independent, accredited surveyor and every purchase WILL ALWAYS BE subject to your satisfaction with the results from your independent survey and your own personal trial run. Used mainly for storage.ĭon't miss out on your opportunity to own this good condition Checkmate high performance! The cuddy could sleep 2, but would be a little tight. Newer upholstery along with the upgraded captain and passenger seats and stored indoors, this Checkmate boat can get you to your favorite spot at incredible speeds of up to 60 mph. She's been well-maintained, clean and ready to go. Powered by a 340hp OMC 5.7L King Cobra Big Block engine (rebuilt in 2020) will reach speeds of around 60mph. Located in Pataskala, Ohio, this 22ft 1989 Checkmate MAX229 high performance boat (freshwater cooling), freshwater use only and always stored indoors. ANY and ALL offers will be put in front of our seller! Submit your offer today!Įxcellent Condition Checkmate MAX229 With Ford 460 Cobra Big Block Freshwater Cooling 10hrs, New Ulphostrey and Seats!! The laws of space and time have been torn asunder, leaving the once-thriving colony filled with nightmarish demons and tortured madmen. In the depths of space and under the shadow of a swirling black hole, the derelict space station Irid Novo has become a prison of horrors. ![]() The premise of Hellpoint should be enough to entice any hardcore horror fan. While Hellpoint delivers on some of these stronger than others, a number of baffling design decisions hold the game back. Soulslike games need to have four things: levels that reward exploration, tight tough combat, big scary bosses, and the sense of being a small adventurer in a much larger lonely world. Luckily, that also makes it pretty easy to break down what Hellpoint does right and what it does wrong. Aside from that, it’s all Dark Souls stuff. The biggest difference comes from a dedicated jump button that can be used to solve puzzles, hunt for clues, and execute powerful jump attacks. You spend stamina to attack/block/dodge, and Axions to level up. You’ve got your sword, your board, and plenty of other weapons and gadgets that range from wildly overpowered to completely useless. But with Hellpoint, the comparison is impossible to avoid. It’s a standard of judgement that I’ve grown increasingly disenfranchised with as games inch away from the genre’s source material. Reviewing Soulslikes is always a bit of a drag, since it essentially boils down to using Dark Souls as a baseline and just pointing out the things the game does better and worse. Unfortunately, they still have a long road to travel. Experience that perhaps someday Hellpoint‘s developer Cradle Games will also have. FromSoftware has had a lot of experience perfecting the formula. On top of that, 5 titles of improvement have elevated expectations even beyond the lofty heights of nostalgia. The millstone of time has since worn down your most worrisome niggles about the horrible camera in Dark Souls or the absurd backstab windows in Demon’s Souls. On the other hand, newer Soulslike titles have inherited the expectations of a franchise that’s been around for 10 years. The ARPG genre as a whole has been so undeniably altered by the shockwave of Dark Souls that every game now has some form of stamina management combat and enemies that respawn at checkpoints. On the one hand, Soulslikes are one of the most popular styles of games on the market. I do not envy the modern Soulslike developer. If Players don't meet the Attributes requirements, they will still be able to be use the Weapon but will have a big penalty. Attributes can be improved by spending points when leveling up.Hellpoint Review – Sci-Fi Soulslike With Some DemonsĪvailable on PC (Reviewed), PS4, and Xbox One ![]() Most Weapons require a certain amount of Attributes to be used. Stats have diminishing returns, so its best to distribute your attributes as you level up.Īs of the release of the Blue Sun DLC, players can now respec their stats via the Respecify Stat Points feature.Īttributes increase the performance of the Player Character and improve other Stats. Most Weapons require a determined amount of Attributes in order to be used effectively. You can see each individual page for more information. ![]() ![]() Melee Weapons can provide the following Stats: Requirements, Bonus, Power, Tenacity (Stat), Leech, Weight and Damage. See each individual Attribute page for more information on how they improve your character. Each level will provide them with one Attribute point. Attributes are increased by leveling up your character and spending points into them. Stats for Hellpoint covers the different attributes and stats of the Playable Character. ![]() I grew up with parents who believed in stocking up so it’s second nature to me and just makes sense. Plus, by eliminating those “quick” runs to the store, you will not be prone to spending more than necessary on impulse items that call your name! Let me clarify something: by stockpiling you are not becoming a doomsdayer or part of some cult…you are simply stocking up on items that your household uses regularly so that you never have to run out and buy it at full price. Grocery stockpiling may be completely foreign to you and it may be a tad bit scary. I also got a great deal on strawberries recently and made jam with them. Last month, Safeway had blueberries for $3.99 each and had a ‘buy 1 get 3 free’ sale! So, I stocked up and froze 24 pints. Since fruit is expensive out of season, I love it when I can score a deal and freeze or can the fruit. I bought 7 months worth of detergent and ended up making $4.75 after coupons and promotions! Now, that’s what I call “royally” stocking up! One of my favorite items to stockpile is fruit. My best grocery stockpiling deal was dishwasher detergent at CVS. When cereal is under a dollar, it’s time to stockpile! As I mentioned before, just keep the 75% off rule in mind as you judge an item’s “stockpiling worthiness.” The 75% off price will be achieved by a sale price stacked with coupons. You should easily be able to get your toothpaste, deodorant, and toilet paper for free. Now my rule of thumb for stockpiling prices is any item 75% off the retail price. spices, olive oil, etc), shampoo, soap, and lotion. If you are just starting out, the best things to stock up on are: toothpaste, toilet paper, paper towels, deodorant, cereal, pantry items (e.g. Obviously, your grocery stockpiling items need to be shelf stable or have the ability to be canned or frozen. An important key to stockpiling as a savings tool is: ONLY buy what your household uses…do not stock up on things or buy in amounts that you won’t use! I know lots of single people out there think they can’t stockpile…why not? Sure, you don’t need to stockpile 20 peanut butters but why not 3-5? You need to develop your stockpile to what YOU personally use in a 3-6 month cycle (or 1 year depending on the item and the sale). Now, everyone’s stockpile will look different and have different amounts of certain things. That step is called grocery “stockpiling.” This is the act of stocking up on items when they are dirt cheap so that you are never in the position of having to pay full price for an item! If you don’t want to stockpile, then extreme couponing isn’t for you. However, it’s often the one step that people tend to avoid. ![]() So, the next step in your quest for coupon royalty is the most critical. By now you should have lots of coupons, have them somewhat organized in a binder and maybe have even scored a deal or two! You are one step closer to being a Coupon Queen/King (thanks to my mom for pointing out that being frugal isn’t gender specific!). |
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